HLA - DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus 2 Infection possibly through Interacting with Viral Mutations

4 Running title: HLA SNPs interact with HBV mutations in liver diseases 5 6 Qi Zhang, Jianhua Yin, Yuwei Zhang, Yang Deng, Xiaowei Ji, Yan Du, Rui Pu, 7 Yifang Han, Jun Zhao, Xue Han, Hongwei Zhang, and Guangwen Cao 8 9 a Department of Epidemiology, Second Military Medical University, Shanghai 200433, China 10 11 b Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second 12 Military Medical University, Shanghai 200433, China 13 14 c Division of Chronic Diseases, Center for Disease Control and Prevention of Yangpu District, 15 Shanghai 200090, China 16 17 Address correspondence to Guangwen Cao, [email protected]. 18 19 Q.Z. and J.Y. contributed equally to this work. 20 21 Word count: Main manuscript, 4319; Abstract, 250; Tables, 7; Figure, 1; References, 51. 22 23 JVI Accepts, published online ahead of print on 4 September 2013 J. Virol. doi:10.1128/JVI.02073-13 Copyright © 2013, American Society for Microbiology. All Rights Reserved.